The latest articles related to Premature Ovarian Failure
While most of the physical findings are harmless, there can be significant medical problems associated with the syndrome. Cardiovascular Price et al. (1986 study of 156 female patients with Turner syndrome) showed a significantly greater number of deaths from diseases of the circulatory system than expected, half of them due to congenital heart defects—mostly preductal [...]
1. Desai P, Patel B, Hazra M: Hydatid Cyst causing obstructed labour: Jr. of O. & G. of India: Vol. 35:No. 2: April, 1985. Pg. 411. 2. Desai P, Udvani H: Unusual case of rupture uterus: Jr. of O. & G. of India: Vol 38 : No. 3 : June 1988. Pg. 371. 3. Desai [...]
First ovarian transplant with cryopreserved ovarian tissue was performed by Dr Kutluk Oktay in 1999. In Sep 2004 ”Prof Donnez” of Louvain in Belgium reported the first successful ovarian birth from slow, or controlled rate, frozen ovarian tissue. In 1997 samples of ovarian cortex were taken from a woman with Hodgkin’s lymphoma and cryo-preserved in [...]
There is some controversy as the accuracy of the tests used to predict poor ovarian reserve. One systematic review concluded that the accuracy of predicting the occurrence of pregnancy is very limited. When a high threshold is used, to prevent couples from wrongly being refused IVF, only approximately 3% of IVF-indicated cases are identified as [...]
Cardiovascular * In biological men, testosterone levels that are either significantly above or below normal are associated with increase cardiovascular risk. This may be causative or simply a correlation. * A single retrospective study in the medical literature of 293 trans men treated with testosterone (range of 2 months to 41 years) by the ”Amsterdam [...]
Fragile X syndrome: Almost all cases of fragile X syndrome are caused by expansion of the CGG trinucleotide repeat in the ”FMR1” gene. In these cases, CGG is abnormally repeated from 200 to more than 1,000 times, which makes this region of the gene unstable. As a result, the ”FMR1” gene is methylated, which silences [...]
Mutations in NR5A1 can produce intersex genitals, absence of puberty, and infertility. It is one cause of arrest of ovarian function in women Adapted from the Wikipedia article Steroidogenic factor 1, under the G. N. U. Free Documentation License. Please also see http://en.wikipedia.org/wiki
Historical background Cryobiology history can be traced back to antiquity. As early as in 2500 BC low temperatures were used in Egypt in medicine. The use of cold was recommended by Hippocrates to stop bleeding and swelling. With the emergence of modern science, Robert Boyle studied the effects of low temperatures on animals. In 1949 [...]
This protein is involved in sex determination. Female missing the ”FOXL2” gene appear male. ”FOXL2” knockout in mature mouse ovaries cause them to develop into testes, however oocytes are still formed. Mutations in this gene are a cause of blepharophimosis syndrome and premature ovarian failure 3. Adapted from the Wikipedia article Forkhead box L2, under [...]
Between 5 and 10 percent of women with POF may spontaneously become pregnant. Currently no fertility treatment has officially been found to effectively increase fertility in women with POF, and the use of donor eggs with In-Vitro Fertilization (IVF) and adoption have become more popular as a means of becoming parents for women with POF. [...]
Serum follicle-stimulating hormone (FSH) measurement alone can be used to diagnose the disease. Two FSH measurements with one-month interval have been a common practice. The anterior pituitary secretes FSH and LH at high levels due to the dysfunction of the ovaries and consequent low estrogen levels. Typical FSH in POF patients is over 40 mlU/ml [...]
VWM is a leukodystrophy which has unique biochemical abnormalities. A unique characteristic of VWM is that only oligodendrocytes and astrocytes are negatively affected while the other neurons seem to be unaffected. This is the central question behind VWM. The real reasons behind this behavior are unknown since the cells are in the brain and have [...]
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Interview with a doctor who talks in detail about the disease and misconceptions about it. POF is a horrible disease that affects lots of young...